Abstract: A 31-year-old female presented with bilateral eyelid edema for 9 days, fever for 8 days and erythema all over the body for 6 days. The patient had a history of a third dose of the one day before the onset of illness. Dermatological examination showed facial edema of erythema, conjunctival congestion in both eyes, erosion around the eyes and mouth, covered with thick blood scab,oral mucosal erosion, edema of erythema on the trunk and upper limbs, and some blisters could be seen in the center of part of the erythema, with tense blister wall, and Nissl's sign (-), an erosion about 7 cm×5 cm on the left upper arm, vulvar mucosal erosion with exudation. The patient was diagnosed as Stevens-Johnson syndrome, treated with methylprednisolone and cyclosporine and the lesions subsided gradually.

Key words: SARS-CoV-2 vaccine, adverse reaction, Stevens-Johnson syndrom