Abstract: In recent years, the use of targeted anti-tumor drugs has gradually occupied a pivotal position in the treatment of malignant tumors. The widespread application of targeted therapies can significantly improve the survival rate of patients, but the adverse skin reactions（ASR） caused by them are common. Classification and analysis of ASR caused by targeted drugs according to different targets can find commonalities and personalities, and provide new ideas for diagnosis and treatment for dermatologists and oncologists. The types of ASR caused by targeted drugs and their treatment measures of cell membrane-related inhibitors, intracellular signaling inhibitors, and immune checkpoint inhibitors are reviewed in this article.

Key words: targeted therapy, immunotherapy, adverse reactions, skin