Abstract: There is currently no standard treatment for palmoplantar pustulosis. Traditional treatments for palmoplantar pustulosis include oral acitretin A, cyclosporine A, and methotrexate, which are often limited due to their adverse effects. In addition to traditional topical drugs, physiotherapy and systemic drugs, new treatments such as biologics and small molecule drugs have recently emerged. This paper reports a case of off-label treatment of palmoplantar pustulosis with apremilast, which achieved satisfactory results.

Key words: palmoplantar pustulosis, apremilast, small molecule drugs, PDE4