Abstract: The traditional oral drugs of palmoplantar pustulosis includes acitretin, methotrexate, cyclosporine A, the use of which are often limited due to adverse reactions. Jak inhibitors such as tofacitinib could affect a series of cytokines by inhibiting the JAK-STAT pathway, and play an immunomodulatory role. The clinical efficacy of JAK inhibitors in psoriasis and atopic dermatitis has been confirmed. We reporte three cases of palmoplantar pustulosis successfully treated with tofacitinib and reviewed the relevant literature.

Key words: tofacitinib, palmoplantar pustulosis, JAK inhibitors