Abstract: The aryl hydrocarbon receptor (AhR), a class of ligand-dependent transcriptional activators, plays an important role in the regulation of immunity and skin barrier function. In recent years, targeted activation of AhR has been shown to be effective in the treatment of psoriasis. This article reviewed the basic features and functions of AhR, as well as the relationship with psoriasis, and the development of therapeutic drugs based on AhR targets.

Key words: psoriasis, aryl hydrocarbon receptor, pathogenic mechanisms, targeted therapies