Abstract: Both patients were elderly farmers with a history of trauma. The skin lesions presented as asymptomatic proliferative plaques. Histopathological examination showed typical sclerotic bodies. Fungal culture identified the fungal as Cladophialophora carrionii. The patient were treated with oral itraconazole 200 mg twice daily, topical fusidic acid cream and sertaconazole nitrate cream. One month later, the patient's skin lesions improved. We summarized the characters of cases reported in literature, which included Cladophialophora carrionii infection in China were mainly middle-aged and elderly people (mean age 53.7 years), and 50% of the patients had a history of trauma. Upper limbs were the most commonly affected sites, and plaques were the most common manifestation. The average course of disease was about 5.4 years, and due to the lack of subjective symptoms, patients often delay seeking medical advice, which may lead to the spread of infection and disability. Cladophialophora carrionii was sensitive to antifungal drugs.

Key words: Cladophialophora carrionii, chromoblastomycosis, fungal infection