China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (1): 69-72.doi: 10.12144/zgmfskin202501069

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Research progress on interleukin-17C in autoimmune skin diseases

YAO Xinyi1, HE Tong1, YANG Xinya1, XU Mingcheng1, ZHANG Junling2   

  1. 1 Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300000, China; 2 Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
  • Online:2025-01-15 Published:2024-12-24

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Abstract: Interleukin-17s(IL-17s) family cytokines have pro-inflammatory effects. It is involved in the occurrence and development of various autoimmune diseases. IL-17C was found to be one of the key members in IL-17s recently. In contrast to IL-17A, which derived from a wide range of immune cells, IL-17C is mainly secreted by epithelial cells and plays a role through the IL-17RE/A receptor complex. Abnormal expression of IL-17C is observed in autoimmune skin diseases such as psoriasis and atopic dermatitis. This article reviews the research progress on the relationship between IL-17C and autoimmune skin diseases.

Key words: interleukin-17C(IL-17C), cytokine, autoimmune skin diseases, psoriasis, atopic dermatitis