Abstract: More and more attention has been paid to the bidirectional interaction of neuro-immunity in the pathophysiology of atopic dermatitis (AD). The interaction between nerve fibers and immune cells is involved in a variety of signal communication. The nervous system modulates immune responses and disease progression through neurotransmitters binding to specific receptors on immune cells. Conversely, activated immune cells release mediators that regulate nerve fiber function, affecting neurotransmitter levels and thereby contributing to the pathogenesis of AD. This review summarizes several classic neurotransmitters and their receptors, focusing on the activation of signaling pathways and the release of inflammatory cytokines, and the mechanisms through which these interactions contribute to immune dysregulation in AD, offering novel insights and therapeutic strategies for clinical treatment.

Key words: neuroimmunity, neurotransmitter, immune cells, cytokines, atopic dermatitis