Abstract: The sudies on high-salt diet mainly focus on cardiovascular and cerebrovascular diseases, however, there are few studies on the association with systemic lupus erythematosus. A high-salt diet is closely associated with the production of autoantibodies and the regulation of immune cells. SLE is typically characterized by impaired apoptotic cell clearance, B-cell immunity, and T-cell signaling. This paper summarizes the research evidence that high-salt diet affects SLE by regulating Th17/Treg cells, Tfh cells and DCs, and reviews the research on high-salt diet in lupus nephritis.

Key words: sodium, dietary, immune cells, systemic lupus erythematosus