Abstract: We report a case of autoimmune polyglandular syndrome type IIIC+D and review the related literature in this paper. A 48-year-old female patient presented with light red patches on the exposed area with itching for 1 month, joint pain for 5 days. She had a 20-year-history of vitiligo.  Physical examination showed light red patches on the exposed area and Gottron papules. Antinuclear antibody was weakly positive, 24-hour urine protein quantification 447.6 mg/24 h. The level of FT3,FT4,TPOAb,TSH were high and TSH was low. Color doppler ultrasonography of thyroid showed hashimoto's thyroiditis, hyperthyroidism. The patient had vitiligo, systemic lupus erythematosus, Hashimoto's thyaroiditis and hyperthyroidism, which was in line with the diagnosis of autoimmune polyglandular syndrome type IIIC+D. The patient was treated with glucocorticoids, hydroxychloroquine sulfate, azathioprine, total glucosides of paeony and anti-hyperthyroidism drugs, and the patient's condition improved.

Key words: autoimmune polyglandular syndromes, vitiligo, systemic lupus erythematosus, Hashimoto's thyroiditis, hyperthyroidism