Abstract: The etiology and pathogenesis of vitiligo has not been fully clarified, which involves  genetics, autoimmune mechanisms, oxidative stress and environmental factors. Suitable animal models are the bases of pathogenesis study. Compared with the spontaneous vitiligo models, induced vitiligo models can be more capable to simulate the pathogenesis and influencing factors of vitiligo. The update of  vitiligo animal models is reviewed in this paper.

Key words: vitiligo, animal model, induced vitiligo model