Abstract: The two patients were females, and the age was 36 and 19 years old respectively. Both patients presented with blisters on the erythema with negative Nikolsky sign. Histopathological examination of the skin showed epidermal parakeratosis, neutrophil infiltration, and liquefaction degeneration of basal cells. Direct immunofluorescence showed that IgA, lgG, and C3 were deposited linearly or zonally on the basement membrane zone. The diagnosis of bullous systemic lupus erythematosus was made according the clinical manifestations and laboratory tests. Both were treated with glucocorticoids and their lesions were improved.

Key words: bullous, systemic lupus erythematosus