China Journal of Leprosy and Skin Diseases ›› 2020, Vol. 36 ›› Issue (4): 227-229.doi: 10.12144/zgmfskin202004227

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Cutaneous Rosai-Dorfman-Destombes disease misdiagnosed as systemic lupus erythematosus: a case report

YAO Yanru1, WANG Jibo1, ZHANG Ting2, WEN Dawei1   

  1. 1 Department of Rheumatology and Immunology, Affiliated Hospital of Qingdao University, Qingdao 266003,China; 2 Department of Rheumatology, Qilu Hospital of Shandong University (Qingdao), Qingdao 266035, China
  • Online:2020-04-15 Published:2020-04-27
  • Contact: WANG Jibo, E-mail: wangjibo2005@126.com

Abstract: A 60-year-old woman presented with progressive erythematous on bilateral face for one year, papules and plaques for 6 months. Skin biopsy showed that large histiocytes exhibited emperipolesis in a background of mixed inflammatory infiltrate in the dermis and subcutaneous tissue. Immunohistochemical stain showed positivity of S-100, CD68 and negativity of CD1a. The skin lesions were improved after prednisone, methotrexate, and thalidomide treatment for two months.

Key words: Rosai-Dorfman-Destombes disease, cutaneous Rosai-Dorfman-Destombes disease, systemic lupus erythematosus