China Journal of Leprosy and Skin Diseases ›› 2025, Vol. 41 ›› Issue (7): 522-523.doi: 10.12144/zgmfskin202507522

• Case Reports • Previous Articles     Next Articles

Tofacitinib monotherapy successfully treated pemphigus vulgaris: a case report

CAO Shan1,2, ZHAO Qing1,2, HUAI Pengcheng1,2, ZHANG Furen1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2025-07-15 Published:2025-07-07

Abstract: JAK inhibitors are medications targeting the Janus kinase family of non-receptor tyrosine kinases, which influences cell proliferation, and immune cell differentiation. We report a case of pemphigus vulgaris who was successfully treated with tofacitinib monotherapy. Complete resolution of mucosal lesions after two months of tofacitinib treatment.

Key words: JAK inhibitor, tofacitinib, pemphigus vulgaris