Abstract: Objective: To determine the clinical characteristics of drug eruption caused by tetanus antitoxin injection. Methods: The clinical data of 42 cases with drug eruption caused by tetanus antitoxin were analyzed respectively. Results: The skin test was negative in 40 patients and positive in 2 patients. Incubation was 6 to 12 days and the average incubation was 6.5 days. The lesions were presented as erythema in injection area in 2 patients and as generalized rash in 40 patients (exanthematous type in 6 patients, urticaria type in 32 and erythema multiforme type in 2). Five of 42 patients accompanied with fever, 5 with voimt and 12 with joint pain. Glucocorticoid was effective in the treatment.Conclusion: The common type of drug eruption caused by tetanus antitoxin injection is urticaria type and some patients have fever, voimt and joint pain. There is no correlation between the drug eruption caused by tetanus antitoxin injection and the result of skin test.

Key words: tetanus antitoxin, drug eruption, skin test