Abstract: Objective：To investigate the expression of TNF-like ligand 1 aberrance (TL1A) and its receptor decoy receptor3 (DcR3) in the skin lesions of the patients with psoriasis vulgaris (PV).. Methods：The expression of TL1A and DcR3 in the skin lesions of 30 patients with PV was tested with SP immunohistochemical and real-time fluorescence quantitative RT-PCR method. Results: The positivity rates of TL1A and DcR3 proteins were 93.3% and 90% in PV, and were 20% and 60% in the normal samples. The expression levels of TL1A mRNA and DcR3 mRNA were (4.909土1.607) and (3.430土1.449) in PV, and (1.250土0.650) and (1.011土0.150) in normal skin. The level of TL1A and DcR3 protein and mRNA were significantly higher in PV than that in normal tissue, with a significant difference.?There was a positively correlation?between the protein level of TL1A and DcR3 in PS（P<0.01）; TL1AmRNA and DCR3mRNA expression in psoriatic lesion was a positive correlation (P<0.05); TL1A mRNA expression in PS and PASI shows no correlation (P>0.05); DcR3 mRNA expression in PS was positively correlation with PASI (P<0.05). Conclusion：TL1A and DcR3 may participate in the pathogenesis of chronic skin inflammation in psoriasis.

Key words: psoriasis vulgaris, TNF-like ligand 1 aberrance, decoy receptor3