播散性浅表性光化性汗孔角化症SLC17A9基因突变分析

Abstract

Abstract: Objective: To identify mutations of SLC17A9 gene in eleven patients with disseminated superficial actinic porokeratosis. Methods: After extracting DNA from peripheral blood, all the exons of SLC17A9 gene and their flanking intronic sequences were amplified by PCR, and then direct sequencing was performed to screen the mutations in the gene. Results: No mutation was found in any of the exons in SLC17A9 gene from the eleven patients. Conclusion: The pathogenesis of the eleven patients with disseminated superficial actinic porokeratosis is not associated with the sequence of coding region in SLC17A9 gene.

Key words: disseminated superficial actinic porokeratosis (DSAP), SLC17A9 gene, mutation

XIA Yang, FU Xi, an, TIAN Hongqing, LIU Hong, ZHANG furen. Analysis of SLC17A9 gene mutations in disseminated superficial actinic porokeratosis[J].China Journal of Leprosy and Skin Diseases, 2016, 32(11): 672-675.

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Analysis of SLC17A9 gene mutations in disseminated superficial actinic porokeratosis

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