Abstract: Objective: To detect the level of microparticles in peripheral blood of patients with psoriasis. Methods: The microparticles from T-cells, B-cells and monocyte of 33 patients with psoriasis vulgaris and 33 healthy controls were isolated by high-speed differential centrifugation. Microparticles from T-cells, B-cells and monocyte were treated with specific labeled monoclonal antibodies respectively and the number of microparticles was detected by flow cytometry. Results: The total number of microparticles derived from T cells, B cells and monocytes in patients was (6.6±0.2)×105, (3.9±0.3)×105 and (4.1±0.2)×105 and those in healthy controls was (2.0±0.3)×105，(1.6±0.3)×105 and (1.1±0.2)×105, with significant difference (P<0.05). The number of microparticles in patients decreased after treatment. And there was a positive correlation between the level of microparticles and PASI in patients with psoriasis vulgaris, especial microparticles from T-cells. Conclusion: The number of microparticles in patients with psoriasis vulgaris increased significantly, which may play a role in the pathogenesis of psoriasis vulgaris.

Key words: psoriasis vulgaris, microparticles, PASI