China Journal of Leprosy and Skin Diseases ›› 2016, Vol. 32 ›› Issue (6): 342-345.

Previous Articles     Next Articles

Detection of the polymorphisms of REL gene in the patients with psoriasis vulgaris in Han nationality of Inner Mongolia

WANGYong 1, HAN Jianwen 2, BAI YunHua 3, SUN Zhiqiang 2, ALATENG Chulu 2, LIU Jia 2, LIDongxia2, LV Xinxiang2, WU Rina2.   

  1. 1. Department of Rheumatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China; 2. Department of Dermatology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China 3. Department of Dermatology, Hulunbeier People’s Hospital, Hulunbeier 021000, China
  • Online:2016-06-15 Published:2018-12-27
  • Contact: HAN Jianwen, E-mail: hanjianwen1981@hotmail.com

PDF (PC)

195

Like

Abstract: Objective: To detect the polymorphisms of REL (v-rel avian reticuloendotheliosis viral oncogene homolog) in Han nationality of Inner Mongolia. Methods：DNA was extracted from the peripheral blood of 301 patients and 292 healthy controls. The polymorphisms of REL gene (rs702873, rs842636, rs13031237 and rs13017599) were genotyped by PCR-based ligase detection reaction (PCR-LDR). Results: The genotype frequencies of rs702873 and rs842636 in the patients were 0.126 and 0.128 and those in controls were 0.182 and 0.181, with significant difference (P<0.05) .There was a linkage disequilibrium of rs702873 and rs842636. There was no significant difference in rs13031237 and rs13017599 between the patients and controls (P>0.05). Conclusions: The polymorphisms of REL gene (rs702873 and rs842636) are associated with psoriasis vulgaris in Han nationality of Inner Mongolia.

Key words: psoriasis vulgaris, single nucleotide polymorphisms