China Journal of Leprosy and Skin Diseases ›› 2017, Vol. 33 ›› Issue (11): 667-671.

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Subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome in children: a case report and literature review

REN Faliang1, TAO Yue2, ZHU Jin3, YANG Huan1, TAN Chunhua1, DONG Qianye1, TAN Qi1, WANG Hua1.   

  1. 1. Department of Dermatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing  400014, China; 2. Department of Dermatology Medical School of Nanjing University Drum Tower Hospital, Nanjing, 210008 China; 3. Diagnosis Center of Clinical Pathology, Chongqing Medical University, Chongqing 400016, China
  • Online:2017-11-15 Published:2018-12-12
  • Contact: TAN Qi, E-mail: tanqimaster@126.com

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Abstract: A female 8-year-old patient presented with skin nodules and plaques for 8 months. She got upper thigh swelling one month ago and fever for one week. Physical examination revealed hepatomegaly and splenomegaly without tenderness. Laboratory examination revealed significant decreased level of blood cells, and increased level of alanine aminotransferase, glutamic-oxalacetic transaminase, c-reactive protein and high ESR impaired blood coagulation elevated ferritin. Immunohistochemical staining showed positivity of CD3, CD8, Granzyme B, βF1 and Ki-67.  Bone marrow biopsy showed proliferous and active. Skin lesion biopsy showed heterocyst in subcutaneous fat. Subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome was made. Relevant literature was reviewed.

Key words: subcutaneous panniculitis-like T-cell lymphoma, hemophagocytic syndrome, children