China Journal of Leprosy and Skin Diseases ›› 2017, Vol. 33 ›› Issue (12): 717-719.

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Analysis of strain distribution and drug sensitivity test of Candida in 93 female patients with genital tract infection

LI Qianhui1, LI He2, LIN Tao1, TANG Chaogui1, JIANG Yuzhang1, JIANG Ming2.   

  1. 1 Department of Clinical Laboratory, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China; 
    2 Department of Dermatology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, China
  • Online:2017-12-15 Published:2018-12-12
  • Contact: LI He, E-mail: hellomrlqh@163.com

Abstract: Objective: To determine characteristics of the strain distribution and drug sensitivity test of Candida in 93 female patients with genital tract infection. Methods: The genital tract secretion specimens were collected from 93 female patients. The Candida isolates were cultured in Sabouraud dextrose agar. The types of Candida isolates were identified by CHRO Magar medium, germ tube test with serum and DL-96 FUNGUS System. The drug sensitivity of Candida isolates was detected by DL-96 FUNGUS System. Results: Out of 91 specimens, 81 strains (87.10%) were identified as Candida albicans, 8 (8.60%) as Candida glabrata, one (1.08%) as Candida dublin strain, one (1.08%) as Candida tropicalis, one (1.08%) as Candida krusei and one (1.08%) as Candida kefyr strain. The drug sensitivity test of Candida albicans showed that the sensitivity rates of amphotericin B and 5-flucytosine were 100.00%, followed by voriconazole (93.83%), fluconazol (85.19%) and itraconazole (62.96%). The drug sensitivity test of Candida glabrata showed that the sensitivity rates of amphotericin B and 5-flucytosine were 100.00%, followed by voriconazole (87.50%), fluconazol (62.50%) and itraconazole (25.00%).  Conclusion: The most Candida species in female genital tract infection is Candida albicans. The most sensitive drugs were amphotericin B and 5-flucytosine.

Key words: female genital tract, Candida species, drug sensitivity test