斑秃,Th22,IL-22,IL-17


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China Journal of Leprosy and Skin Diseases ›› 2017, Vol. 33 ›› Issue (3): 129-131.

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Peripheral blood levels of Th22 and its associated cytokines in the patients with alopecia areata

WU Songtao1, ZHOU Ying2, HE Ping3, HUANG Li1, HUANG Guiyi4   

  1. 1. Changde Institute of Dermatology and Venereology, Changde 415000, Hunan, China;

    2. Department of Dermatovenerology, the Second Xiangya Hospital of Central South University, Changsha 410000, China;

    3. Department of Dermatovenerology, the First People's Hospital of Changde,Changde 415000, Hunan, China;

    4. Nanfeng County Institute of Dermatology and Venereology, Nanfeng 344500, Jiangxi, China

  • Online:2017-03-15 Published:2018-12-14
  • Contact: HUANG Guiyi, E-mail: hxfu6688@126.com

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Abstract:

Objective: To detect the Th22 and its associated cytokines in the patients with alopecia areata. Methods: The levels of Th22 and associated cytokines (IL-22 and IL-17) in 38 patients with alopecia areata and 38 healthy controls were detected by flow cytometry and ELISA. Results: The expression levels of Th22, Th17, IL-17+ IL-22+, CD4+, IFN-gamma+ IL-22+ CD4+ T, IL-22 and IL-17 in the parents were higher than those in controls (P<0.05) and all the cytokines mentioned above in the patients with severe alopecia areata were higher than those in the patients with mild alopecia areata (P<0.05). Conclusion: The levels of Th22 and cytokines in the patients with alopecia areata are increased.

?r?n>?< 008e="Calibri" >IL-17+IL-22+CD4+、IFN-γ+IL-22+CD4+T及血清IL-22、IL-17水平均高于正常对照组（P<0.05）；重型斑秃和活动期患者高于轻型斑秃患者和稳定期患者的表达（均P<0.05）。结论：Th22及其细胞因子在斑秃患者中表达升高。ont-fam?Cl?< 008hansi-font-family:Calibri;mso-bidi-font-family:'Times New Roman';font-size:10.5000pt;mso-font-kerning:1.0000pt;" >4. Nanfeng County Institute of Dermatology and Venereology, Nanfeng 344500, Jiangxi, China

Key words: alopecia areata')">

alopecia areata, Th22, IL-22, IL-17