全反式维甲酸对银屑病角质形成细胞间隙连接通信的影响

doi:10.12144/zgmfskin202005316

Abstract

Abstract: Gap junctional intercellular communication (GJIC) is the ubiquitous communication mode in multicellular organisms and the function is achieved by connexin (Cx). A few of studies have showed the correlations between connexin 43 (Cx43) and psoriasis. The all-trans retinoic acid (ATRA) may affect the GJIC function of psoriatic keratinocytes. The effect of all-trans retinoic acid on gap junctional intercellular communication of keratinocytes in psoriasis is reviewed in this paper.

Key words: ATRA, GJIC, psoriasis, Cx43, IL-22

LIANG Xiaodong, DENG Xinhua, LI Chunhong, LIANG Jingyao, ZHANG Xibao. Update of the effect of all-trans retinoic acid on gap junctional intercellular communication of keratinocytes in psoriasis[J].China Journal of Leprosy and Skin Diseases, 2020, 36(5): 316-320.

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Update of the effect of all-trans retinoic acid on gap junctional intercellular communication of keratinocytes in psoriasis

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