IL-17拮抗剂治疗对TNF-α拮抗剂抵抗的特殊类型银屑病一例

doi:10.12144/zgmfskin202305353

Abstract

Abstract: We reported a case of psoriatic arthritis using conventional dose of TNF-αinhibitor after controlling the disease with high dose methotrexate. After three years of maintenance therapy, the patient occurred skin lesions on the trunk and both lower limbs.The patient was treated with IL-17 inhibitor and TNF-αinhibitor until the lesion disappeared, IL-17 inhibitor monotherapy for 8 weeks, the lesions were completely subsided and no recurrence of joint symptoms.

Key words: psoriatic arthritis, psoriasis vulgaris, IL-17 inhibitor, Ixekizumab

CAO Shan, SUN Yonghu, ZHAO Qing, LIU Hong, ZHANG Furen. IL-17 inhibitor treated a specific type of psoriasis resistant to TNF-α inhibitor[J].China Journal of Leprosy and Skin Diseases, 2023, 39(5): 353-354.

[1]	SANG Xu, WANG Zhenzhen, LI Wenchao, LIU Hong, ZHANG Furen. Cost-effectiveness analysis of biologic agents in the treatment of moderate-to-severe plaque psoriasis [J]. China Journal of Leprosy and Skin Diseases, 2023, 39(5): 344-349.
[2]	GU Yuanxia, WANG Yiyi, XIAO Yue, LI Wei. Update of subclinical psoriatic arthritis [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(9): 650-652.
[3]	SUN Yonghu, CAO Shan, ZHAO Qing, LI Jianke, WANG Xiuhuan, ZHANG Furen. High dose methotrexate successfully treated severe arthropathic psoriasis: a case report [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(8): 540-541.
[4]	LIU Chengling, HE Zan, REN Dan, WANG Jingyu, DU Zhimin, SUN Yufa, ZHAO Hua. Association of psoriasis and psoriatic arthritis with ulcerative colitis: a meta-analysis [J]. China Journal of Leprosy and Skin Diseases, 2022, 38(1): 8-13.
[5]	GAO Yingli, LI Yuzhen. Advances in the treatment of psoriatic arthritis by tofacitinib [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(6): 402-405.
[6]	CHEN Zuoxi, ZHANG Yuan, ZHAO Qing, SHI Zhongxiang, SUN Yonghu, ZHANG Furen. Treatment of childhood pustular psoriasis with ixekizumab: a case report [J]. China Journal of Leprosy and Skin Diseases, 2021, 37(12): 801-803.
[7]	LU Xiaoou, WANG Haiyan, CAO Xinyuan, YAN Jie, CHEN Hongquan, WANG Shaoyan. Long-termed efficacy of secukinumab 300 mg and 150 mg in the treatment of psoriatic arthritis: a meta-analysis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(8): 454-460.
[8]	QIAN Qing, GAO Chunyan, SHEN Yuhong, SONG Shishen, GUO Naizhou, GAO Wen. Expression of CD47 in peripheral blood myeloid dendritic cells in the patients with psoriasis vulgaris [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(6): 330-334.
[9]	CHEN Jingjing, NI Na, WANG Yahua, YUAN Feng. Association between HLA alleles and psoriatic arthritis: a meta-analysis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(5): 267-271.
[10]	ZHANG Ran, WANG Yiyi, DING Li, LI Gaojie, YANG Min, WANG Liyun, QIU Li, LI Wei. Comparison of joint changes demonstrated by musculoskeletal ultrasound imaging between the patients with moderate to severe psoriasis and the patients with psoriatic arthritis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(11): 643-648.
[11]	LU Changpei, JING Haixia, WANG Runchao, WANG Heng, LUO Ting, BU Qingyun. Meta analysis of the efficacy and safety of guselkumab in the treatment of psoriatic arthritis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(11): 667-671.
[12]	WANG Yiyi, LI Gaojie, LAN Xiaomeng, CHEN Zerong, LI Wei. Update of biomarkers in psoriatic arthritis [J]. China Journal of Leprosy and Skin Diseases, 2020, 36(10): 636-640.
[13]	SUN Xianqi, LI Yuzhen. The expression of DUSP1 and DUSP4 in psoriasis vulgaris [J]. China Journal of Leprosy and Skin Diseases, 2019, 35(11): 664-666.
[14]	DENG Wei, ZHANG Xiaoyan. IL-17 and IL-23 targeting therapies in psoriasis [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(7): 437-440.
[15]	FEI Wenmin , TANG Huayang , YANG Sen , ZHANG Xuejun , . The changes of microcirculation in the skin lesions and nail fold in the patients with psoriasis vulgaris [J]. China Journal of Leprosy and Skin Diseases, 2018, 34(4): 203-206.

IL-17 inhibitor treated a specific type of psoriasis resistant to TNF-α inhibitor

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10