Abstract: The significantly antioxidant effect of paeoniflorin is reported in many reports recently. The mechanism of antioxidant stress relating to inhibition of the hyperoxidation, enhancing antioxidant capacity, improving mitochondrial function, inhibiting calcium overload, anti-apoptosis, inhibiting or activating relative signaling pathways ect, which is reviewed in this article.

Key words: paeoniflorin, oxidative stress