大疱性鱼鳞病样红皮病遗传学研究进展

China Journal of Leprosy and Skin Diseases ›› 2017, Vol. 33 ›› Issue (6): 381-384.

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Update of the genetics of bullous congenital ichthyosiform erythroderma

CHEN Pingjiao¹, LI Changxing², ZENG Kang¹, ZHANG Xibao³.

1. Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; 2. Department of Dermatology, Dongguan Sixth People's Hospital, Dongguan, 523008, China; 3. Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, China

Online:2017-06-15 Published:2018-12-19
Contact: ZENG Kang, E-mail: npfkzk@163.com ZHANG Xibao, E-mail: zxibao@126.com

Abstract

Abstract: Bullous congenital ichthyosiform erythroderma (BCIE) is an autosomal dominant inherited disease and the mutations of KRT1 and KRT10 are the key in the pathogenesis of the disease. Studies on the genetics of BCIE have been developed in recent years. In this review, we summarize the patterns, strategies and the update progress of the genetic researches on BCIE.

Key words: bullous congenital ichthyosiform erythroderma, genetics, keratin1and keratin10, gene mutation

CHEN Pingjiao, LI Changxing, ZENG Kang, ZHANG Xibao.. Update of the genetics of bullous congenital ichthyosiform erythroderma[J].China Journal of Leprosy and Skin Diseases, 2017, 33(6): 381-384.

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Update of the genetics of bullous congenital ichthyosiform erythroderma

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