China Journal of Leprosy and Skin Diseases ›› 2017, Vol. 33 ›› Issue (9): 531-535.

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Effects of Saussurea laniceps on human fibroblasts proliferation affected by UVA irradiation

ZHENG Bowen1, RUAN Guanghong1, NI Macili2, LU Rongdawa2, QU Hongye3, HUANG Xiangzhong4, LI Bing5, CHENG Wenxiong5, XIA Yujie5, DENG Dangqi6.   

  1. 1. Department of Dermatology,  the Second People Hospital of Yunnan Province, the Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, China; 
    2. Department of tibetan Medicine, the People Hospital of Deqin County, Diqing 674500, China;
    3. Department of Oral Rehabilitation, the Dental Hospital of Yunnan Province, Kunming 650101, China; 
    4. Key Laboratory of Chemistry, Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University,  Kunming 650504, China; 
    5. Center for Drug Safety Evaluation, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;
    6. Department of Dermatology, the Second Affiliated Hospital of Kunming Medical university, Kunming 650101, China
  • Online:2017-09-15 Published:2018-12-05
  • Contact: XIA Yujie, E-mail: xiayujie@mail.kiz.ac.cn DENG Danqi, E-mail: danqid128@sina.com

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Abstract: Objective: To determine the protective effects of the extract from Saussurea laniceps on the proliferation of human fibroblasts induced by UVA. [WT5”HZ]Methods: The extract from Saussurea laniceps was prepared and the cultured human fibroblasts were divided into normal control group, UVA group and UVA+ Saussurea laniceps group. The cell proliferation activity was detected by CCK8 and the OD of cells was detected. Results: Dead cells in UVA+ Saussurea laniceps group were less than 5%, which was less than that in UVA group (20%～30%). OD in UVA+ Saussurea laniceps group was 1.16±0.22, which was higher than that in UVA group (0.5±0.12), with a significant difference (P<0.05). Conclusion: The extract of Saussurea laniceps has protective effects on human fibroblasts proliferation induced by UVA.

Key words: saussurea laniceps, ultraviolet, UVA, human fibroblasts