Abstract: Mycoplasma genitalium (Mg) is widely recognized as one of the important pathogens and it may cause non-gonococcal urethritis in males. Tetracyclines, macrolides and quinolones are effective in the treatment of the disease. Many recent studies have shown that resistance to doxycycline and azithromycin in Mg is more serious, and there are more reports of treatment failure with moxifloxacin. The update of the drug resistance loci of Mg and treatment is reviewed in this paper.

Key words: Mycoplasma Genitalium, doxycycline, azithromycin, moxifloxacin, drug resistance