Abstract: Circumscribed palmar or plantar hypokeratosis (CPH) is a rare benign skin condition, characterized by well-demarcated, depressed, erythematous patches on the palms and soles. There is no standardized treatment protocol for this disease. There have been some reports of successful treatment of CPH with liquid nitrogen cryotherapy abroad, but not in China. We report one relevant case in this article. A 64-year-old female presented with a depressed erythema on the thenar eminence of her left hand for 7 years. After three times of liquid nitrogen cryotherapy, the lesion completely subsided. There was no recurrence after 18 months of follow-up, and no severe adverse reactions were observed.

Key words: liquid nitrogen cryotherapy, circumscribed palmar or plantar hypokeratosis