Abstract: Objective: To compare the efficacy of liquid nitrogen cryotherapy and Q-switched laser in the treatment of seborrheic keratosis. Methods: The patients with seborrheic keratosis from June 2017 to February 2020 in our hospital were randomly divided into liquid nitrogen cryotherapy group and Q-switched laser group. Results: A total of 170 patients were enrolled, including 85 cases with 245 lesions in the liquid nitrogen cryotherapy group and 85 cases with 218 lesions in the Q-switched laser group. In liquid nitrogen cryotherapy group, 238 lesions (97.14%) were cured, 7 (2.86%) were markedly effective, the total effective rate was 100%, 12 lesions (4.9%) left pigmentation after six months of treatment. In the Q-switched laser group, 213 lesions (97.71%) were cured, 5 (2.29%) were markedly effective, the total effective rate was 100%, 8 lesions (3.67%) left pigmentation after six months of treatment. There was no significant difference of recovery rate, total effective rate and the occurrence rate of pigmentation (Ps>0.05). Conclusion: The liquid nitrogen cryotherapy and Q-switched laser in the treatment of seborrheic keratosis are equally effective with no obvious adverse reaction.

Key words: seborrheic keratosis, liquid nitrogen cryotherapy, Q-switched laser