Abstract: In recent years, obesity has emerged as a global public health concern. It is not only intricately associated with metabolic disorders but also exerts a substantial influence on skin health, particularly in relation to the onset and progression of atopic dermatitis. This review provides a systematic review of recent research advances on the effects of obesity on atopic dermatitis, focusing on how obesity—as a chronic state of mild inflammation—modulates the immune system, skin barrier function, and pruritus mechanisms, thereby offering theoretical insights for mechanistic studies and clinical interventions in obesity-associated atopic dermatitis.

Key words: obesity, skin inflammation, atopic dermatitis, immune regulation