中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (9): 545-548.doi: 10.12144/zgmfskin201909545

• 短篇论著 • 上一篇    下一篇

米诺环素治疗角层下脓疱病一例并文献复习

王萍萍1  孙扬2  雷娜1  于腾3   

  1. 1济宁医学院临床医学院，山东济宁，272000
    2济宁市第一人民医院心胸外科，山东济宁，272000
    3济宁市第一人民医院皮肤科，山东济宁，272000
  • 出版日期:2019-09-15 发布日期:2019-09-16
  • 通讯作者: 于腾，E-mail: 20002437@qq.com

Minocyline in the treatment of subcorneal pustular dermatosis: a case report and literature review

WANG Pingping1, SUN Yang2, LEI Na1, YU Teng3   

  1. 1. School of Clinical Medicine, Jining Medical University, Jining 272000, China; 
    2. Department of Cardiothoracic Surgery, Ji-ning No.1 People's Hospital, Jining 272000, China; 
    3. Department of Dermatology, Ji-ning No.1 People's Hospital, Jining 272000, China
  • Online:2019-09-15 Published:2019-09-16
  • Contact: YU Teng, E-mail: 20002437@qq.com

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摘要： 报道米诺环素治疗角层下脓疱病1例并对相关文献进行复习。患者，女,14岁，臀部、腹股沟、双下肢屈侧反复出现红斑、脓疱6年，加重半月。组织病理学表现为角质层下脓疱，疱内有中性粒细胞浸润，免疫荧光示表皮细胞间及基底膜IgG、IgA、IgM、C3阴性。结合临床表现及病理学检查，确诊为角层下脓疱病。给予口服米诺环素，外用地奈德乳膏治疗，1个月后皮损消退,维持治疗2个月，随访6个月，未复发。

关键词: 角层下脓疱病, 米诺环素

Abstract: One patient with subcorneal pustular dermatosis was reported and the related literature was reviewed. A 14-year-old girl presented with erythemas and pustules over the lower limbs, buttocks and groin for six years with aggravation for 15 days. Histopathology showed subcorneal pustular dermatosis and infiltration of neutrophil. Direct immunofluorescence (DIF) revealed negative deposition of IgG, IgA, IgM and C3 in the intercellular space of the epidermis and the basement membrane. The diagnosis of subcorneal pustular dermatosis was made. The lesions subsided gradually after 1 month of oral  minocycline and topical desonide cream. No recurrence was observed after maintenance therapy of two months and follow up of six months.

Key words: subcorneal pustular dermatosis, minocycline