中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (11): 701-704.doi: 10.12144/zgmfskin201911701

• 综述 • 上一篇    

角质形成细胞和成纤维细胞对白癜风发病和治疗的影响

李媛媛  佘慧慧  钱龙宝  韦士才   

  1. 南京医科大学第四附属医院（南京市浦口医院）皮肤科，江苏南京，210000
  • 出版日期:2019-11-15 发布日期:2019-11-20
  • 通讯作者: 韦士才，E-mail: 171764603@qq.com

Effect of keratinocyte and fibroblast on the pathogenesis and treatment of vitiligo

LI Yuanyuan, SHE Huihui, QIAN Longbao, WEI Shicai   

  1. Department of Dermatology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
  • Online:2019-11-15 Published:2019-11-20
  • Contact: WEI Shicai, E－mail: 171764603@qq.com

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摘要： 黑素细胞在白癜风发病及治疗中是最关键的一环，但表皮、真皮间的沟通联系对皮损及非皮损皮肤的功能均具有重要影响，其中角质形成细胞、成纤维细胞及细胞外基质等非黑素细胞起了重要作用，并影响白癜风的发病。本文从细胞因子、氧化应激等角度总结了角质形成细胞、成纤维细胞对白癜风发病的影响及在临床治疗中的作用机制。

关键词: 白癜风, 角质形成细胞, 成纤维细胞, 黑素细胞

Abstract: Melanocyte is the key point in vitiligo, but the communication between epidermal and dermal cells may strictly affect the function of skin and the onset of vitiligo, such as keratinocyte, fibroblast and extracellular matrix. The effect of non-melanocytic skin cells on vitiligo and the treatment mechanism is summarized in the viewpoint of cytokines and oxidative stress in this paper. 

Key words: vitiligo, keratinocyte, fibroblast, melanocyte