中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (1): 20-23.doi: 10.12144/zgmfskin202001020

• 论著 • 上一篇    下一篇

广西麻风患者HLA-B*13:01基因检测预防DDS综合征效果分析

段启志,许凤妮,李伟,张杰,朱邦勇,王砚蕾,王宏,李峥,胡冠豪,周志光,黄耿,韦江平,秦雁
  

  1. 广西皮肤病防治研究所，南宁，530003
  • 出版日期:2020-01-15 发布日期:2020-03-16
  • 通讯作者: 许凤妮，E-mail: xiaonianyin@163.com

Evaluation of prospective HLA-B*13:01 screening to prevent dapsone hypersensitivity syndrome in leprosy patients in Guangxi Province

DUAN Qizhi, XU Fengni, LI Wei, ZHANG Jie, ZHU Bangyong, WANG Yanlei, WANG Hong, LI Zheng, HU Guanhao, ZHOU Zhiguang, HUANG Geng, WEI Jiangping, QIN Yan   

  1. Guangxi Zhuang Autonomous Region Institute of Dermatology，Nanning 530003，China
  • Online:2020-01-15 Published:2020-03-16
  • Contact: XU Fengni, E-mail: xiaonianyin@163.com

PDF (PC)

87

摘要： 目的：评价基因位点HLA-B*13:01检测在广西麻风患者中预防氨苯砜综合征(DHS)的应用效果。方法：纳入广西新发麻风患者进行前瞻性队列研究。HLA-B*13:01基因检测阳性者给予剔除氨苯砜的替代方案治疗，阴性者给予WHO标准联合化疗方案治疗，随访8周判断是否发生DHS。回顾性分析既往麻风患者的病历资料，比较两个时间段DHS的发生率。结果：2015年7月1日至2018年12月31日纳入126例患者进行HLA-B*13:01基因检测，阳性36例(28.6%)，阴性90例，均未发生DHS。回顾2012年1月1日至2015年6月30日的180例患者，发生DHS 8例(4.4%)。两组DHS发生率比较，差异具有统计学意义(P=0.042)。结论：疗前检测能降低广西麻风患者DHS发生率。

关键词: 麻风, 氨苯砜, 氨苯砜综合征, HLA-B*13:01

Abstract: Objective: To evaluate the value of prospective HLA-B*13:01 screening for reduction of the incidence of dapsone hypersensitivity syndrome (DHS). Methods: A prospective cohort study in the patients with newly diagnosed leprosy was conducted in Guangxi Province. The patients with HLA-B*13:01-positive were treated with alternative treatment without dapsone and those with negative HLA-B*13:01 gene were treated with WHO standard combination chemotherapy regimen. All patients were followed up for 8 weeks. The occurrence rate of DHS in those patients was compared with historical occurrence rate. Results: From July 1, 2015 to December 31, 2018, 126 patients underwent genotyping, of those 36 were HLA-B*13:01-positive (28.6 %), 90 were HLA-B*13:01-negitive. No DHS was occurred in all patients. From January 1, 2012 to June 31, 2015, the historical incidence rate of DHS was 4.4% in 180 individuals. There was a statistically significant difference in the incidence rate of DHS between the two groups (P=0.042). Conclusion: The frequency prospective screening of HLA-B*13:01 can  significantly reduce the occurrence of DHS in the patients with leprosy in Guangxi Province. 

Key words: leprosy, dapsone, dapsone hypersensitivity syndrome, HLA-B*13:01