中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (5): 307-312.doi: 10.12144/zgmfskin202005307

• 综述 • 上一篇    下一篇

程序性细胞死亡因子-1在过敏性疾病中的研究进展

韩悦,姚煦   

  1. 中国医学科学院北京协和医学院皮肤病研究所，南京，210042
  • 出版日期:2020-05-15 发布日期:2020-05-28
  • 通讯作者: 姚煦，E-mail: dryao_xu@126.com

The role of programmed cell death-1 in allergic diseases

HAN Yue, YAO Xu   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2020-05-15 Published:2020-05-28
  • Contact: YAO Xu, E-mail: dryao_xu@126.com

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摘要： 程序性细胞死亡因子-1（PD-1）是CD28分子家族的成员之一，表达于多种免疫细胞表面。一直以来，PD-1被认为是传统CD4+T细胞的负性调节因子，然而近几年它调节T细胞活性和功能的作用逐渐被揭示。诸多研究表明PD-1的配体PD-L1和PD-L2参与调节T细胞的活化和耐受性。本文对PD-1及其配体在过敏性疾病中的作用机制进行了综述。

关键词: PD-1, 过敏性疾病, 配体, T细胞

Abstract: Programmed death -1 (PD-1) is one of the members of CD28 family molecules  expressed on the surface of a variety of immune cells. PD-1 has traditionally been considered as a negative regulator of CD4+T cells. However, its role in regulating the activities and function of T cells has been gradually revealed in recent years. Studies have shown that the ligands of PD-1, PD-L1 and PD-L2 can regulate the activation and tolerance of T cells. The role of PD-1 and its ligands in allergic diseases is reviewed in this paper.

Key words: PD-1, allergic diseases, ligands, T cells