中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (7): 403-406.doi: 10.12144/zgmfskin202007403

• 论著 • 上一篇    下一篇

替代方案治疗HLA-B*13:01阳性的多菌型麻风患者对细菌指数的影响

段启志,许凤妮,李伟,张杰,朱邦勇,胡冠豪,王砚蕾,王宏,李峥,黄耿,韦江平,秦雁   

  1. 广西皮肤病防治研究所，南宁，530003
  • 出版日期:2020-07-02 发布日期:2020-07-02
  • 通讯作者: 许凤妮，E-mail: xiaonianyin@163.com

The effect of alternative treatment of leprosy on bacteriological index in HLA-B*13:01-positive multi-bacillary leprosy patients

DUAN Qizhi, XU Fengni, LI Wei, ZHANG Jie, ZHU Bangyong, HU Guanhao, WANG  Yanlei, WANG Hong, LI Zheng, HUANG Geng, WEI Jiangping, QIN Yan   

  1. Guangxi Zhuang Autonomous Region Institute of Dermatology, Nanning 530003, China
  • Online:2020-07-02 Published:2020-07-02
  • Contact: XU Fengni, E-mail: xiaonianyin@163.com

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摘要： 目的：比较HLA-B*13:01基因检测阴性和阳性的新发多菌型麻风患者接受含或不含氨苯砜的治疗方案对细菌指数的影响。方法：HLA-B*13:01基因检测阳性者接受替代方案治疗(不含氨苯砜),阴性者服用世界卫生组织的联合化疗方案（WHO-MDT），比较两组患者在治疗前后细菌指数（BI）的变化。结果：替代方案组随访1年、2年和3年病例数分别为19例、14例和13例，疗前平均BI分别为3.31、3.29和3.54，末次检查平均BI分别为2.63、1.80和1.45；WHO-MDT组病例数分别为35例、33例和24例，治疗前平均BI分别为3.31、3.19和3.30，末次检查平均BI分别为2.22、1.68和0.81。替代方案组和MDT组中随访1年、2年、3年患者的BI变化值分别比较，差异均无统计学意义，（均P＞0.05）。结论：从BI变化看，替代方案和WHO-MDT对多菌性麻风的治疗同样有效。

关键词: 麻风, 氨苯砜, 细菌指数, HLA-B*13:01

Abstract: Objective: To compare the effects of alternative regimen and WHO-MDT on the bacteriological index (BI) between the multi-bacillary patients with positive HLA-B*13:01 and negative HLA-B*13:01. Methods: Patients with a positive HLA-B*13:01 were treated with alternative treatment (without dapsone), and whose with negative HLA-B*13:01 were treated with WHO-MDT regimen. The change of BI before and after treatment in the two groups was compared. Results: The number of patients, who was followed-up for one, two and three years was 19, 14 and 13 in the alternative regimen group. The mean BI decreased from 3.31+, 3.29+ and 3.54+ before treatment to 2.63+, 1.80+ and 1.45+ respectively. The number of patients, who was followed-up for one, two and three years was 35, 33 and 24 in the WHO-MDT group. The mean BI decreased from 3.31+, 3.19+ and 3.30+ to 2.22+, 1.68+ and 0.81+. BI change did not show a significant difference between the two groups (Ps＞0.05). Conclusion: The alternative regimen is as effective as WHO-MDT in terms of the change of BI among the multibacillary leprosy patients. 

Key words: leprosy, dapsone, bacteriological index, HLA-B*13:01