中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (6): 365-368.doi: 10.12144/zgmfskin202106365

• 论著 • 上一篇    下一篇

5-氨基酮戊酸光动力治疗基底细胞癌疗效评价

杨永华,裴晓燕,赵伟,刘鑫洲,单晓峰,田洪青   

  1. 山东第一医科大学附属皮肤病医院（山东省皮肤病医院，山东省皮肤病性病防治研究所），济南，250022
  • 出版日期:2021-06-15 发布日期:2021-05-27
  • 通讯作者: 田洪青，E-mail: tianhq2006@126.com

Assessment the efficacy of 5-aminolevulinic acid mediated photodynamic therapy for the treatment of basal cell carcinoma

YANG Yonghua, PEI Xiaoyan, ZHAO Wei, LIU Xinzhou, SHAN Xiaofeng, TIAN Hongqing   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Prouincial Institute of Dermatology and Veneorology, Shandong Fist Medical Univesity, Jinan 250022, China 
  • Online:2021-06-15 Published:2021-05-27
  • Contact: TIAN Hongqing, E-mail: tianhq2006@126.com

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摘要： 目的：评价5-氨基酮戊酸光动力(ALA-PDT) 治疗基底细胞癌的疗效及安全性。方法：回顾2016-2019年我院进行ALA-PDT治疗的17例基底细胞癌患者（浅表型14例，结节型3例）的临床资料。结果：14例浅表型基底细胞癌患者中13例患者皮损消退，仅留轻微色素沉着或色素减退，2例复发,1例于治疗后6个月后复发，1例于治疗后10个月后复发。3例结节型患者皮损面积缩小>50％。所有患者均未发生严重不良反应。结论：光动力治疗浅表型基底细胞癌临床效果好，复发率低，较为安全，对于结节型基底细胞癌治疗效果较差。

关键词: 光动力, 基底细胞癌

Abstract: Objective: To assess the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of basal cell carcinoma. Methods: The data of 17 patients with basal cell carcinoma（BCC）(including 14 cases of superficial BCC and 3 cases of nodular BCC) treated by ALA-PDT were analyzed retrospectively. Results: Of 14 patients with superficial BCC, the lesions in 13 cases were in complete remission with slight pigmentation or hypopigmentation left. Two of them recurred at month 6 and month 10 after treatment respectively. The size of the lesions in 3 patients with nodular BCC reduced by 50%. There was no obvious adverse reaction in all patients. Conclusion: ALA-PDT has good clinical effect and low recurrence rate for the treatment of superficial BCC. However, it has low efficacy for the treatment of nodular BCC.

Key words: photodynamic therapy, basal cell carcinoma