中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (8): 577-580.doi: 10.12144/zgmfskin202208577

• 综述 • 上一篇    

硬化性苔藓的免疫学和分子生物学机制研究进展

吕嘉琪,常建民   

  1. 北京医院皮肤科 国家老年医学中心 中国医学科学院老年医学研究院，北京，100730
  • 出版日期:2022-08-15 发布日期:2022-06-23

Update of the immunological and molecular biological mechanisms of lichen sclerosus

LYU Jiaqi, CHANG Jianmin   

  1. Department of Dermatology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Online:2022-08-15 Published:2022-06-23

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摘要： 硬化性苔藓是一种慢性炎症性皮肤病，最常累及女性生殖器皮肤，严重影响患者的生活质量。目前本病确切的发病机制尚不清楚，治疗方面仍存争议，了解其免疫学和分子生物学机制有助于为本病的临床用药提供新选择，为今后开展有关硬化性苔藓的基础研究提供新思路。本文根据目前国内外研究现状，就硬化性苔藓的免疫学和分子生物学机制研究进展进行综述。

关键词: 硬化性苔藓, 免疫, 细胞因子, 生物大分子

Abstract: Lichen sclerosus is a chronic inflammatory skin disease that most often involves female genital skin, which seriously affects the quality of life of patients. The exact pathogenesis of the disease is still unclear and the treatment is controversial. Understanding the immunological and molecular biological mechanisms of the disease can help provide new options for the treatment of the disease and provide new ideas for future basic research of lichen sclerosus. In this paper, we review the progress of research on the immunological and molecular biological mechanisms of lichen sclerosus.

Key words: lichen sclerosus, immunity, cytokine, biomacromolecule