中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (5): 295-297.doi: 10.12144/zgmfskin202205295

• 论著 • 上一篇    下一篇

自身免疫性大疱病合并银屑病20例临床分析

古元霞1,詹同英1，2,周兴丽1,李薇1   

  1. 1四川大学华西医院皮肤性病科、罕见病中心，成都，610041；2电子科技大学医学院附属妇女儿童中心医院/成都市妇女儿童中心医院皮肤科，成都，610073
  • 出版日期:2022-05-15 发布日期:2022-03-15
  • 通讯作者: 李薇，E-mail: liwei476@wchscu.cn

Clinical analysis of 20 patients with autoimmune blistering disease complicated with psoriasis

GU Yuanxia1, ZHAN Tongying1，2, ZHOU Xingli1, LI Wei1   

  1. 1 Department of Dermatovenereology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu 610041, China;
    2 Department of Dermatology, Wowen's and Children's Hospital Affiliated to Medical College of Chengdu University of Electronic Science and Technology/Chengdu Women's and Children's Central Hospital, Chengdu 610073, China
  • Online:2022-05-15 Published:2022-03-15
  • Contact: LI Wei, E-mail: liwei476@wchscu.cn

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摘要： 收集2011年1月1日至2021年9月30日就诊于四川大学华西医院的自身免疫性大疱病合并银屑病患者的资料，对其临床表现、组织病理、免疫病理、血清学特异性抗体、治疗和转归等进行回顾性分析。 共分析20例自身免疫性大疱病合并银屑病患者，男14例，女6例，平均年龄（64.75±13.13）岁，其中17例患者表现为银屑病先于自身免疫性大疱性疾病发生，平均时间（18.03±14.69）年。治疗上采用糖皮质激素和（或）免疫抑制剂治疗，15例患者皮损控制良好，病情较稳定，4例患者失访，1例死亡。自身免疫性大疱病合并银屑病临床少见，临床工作中应警惕两种疾病并发的情况。

关键词: 自身免疫性大疱病, 银屑病, 临床分析

Abstract: The data of the patients diagnosed as autoimmune blistering disease complicated with psoriasis in our hospital from January 2011 to September 2021 was analyzed retrospectively.  Twenty patients with autoimmune blistering disease complicated with psoriasis were collected, including 14 males and 6 females. The median age was (64.75±13.13) year. There were 17 patients who had developed psoriasis before autoimmune bullous disease with an average duration of (18.03±14.69) years. All patients were treated with systemic corticosteroids and/or immunosuppressive agents. No new blister lesions occurred and psoriatic lesions remained stable in 15 patients. Four cases were lost follow-up and one died. Autoimmune blistering disease complicated with psoriasis was rare, and the coexistence of two diseases should be noted.

Key words: autoimmune blistering disease, psoriasis, clinical analysis