中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (9): 632-634.doi: 10.12144/zgmfskin202209632

• 病例报告 • 上一篇    下一篇

海分枝杆菌皮肤感染一例

陈妍1,2,3,4,尚盼盼1,2,3,4,宋营改1,2,3,4,王明悦1,2,3,4   

  1. 1北京大学第一医院皮肤性病科，北京，100034；
    2国家皮肤与免疫疾病临床医学研究中心，北京，100034；
    3皮肤病分子诊断北京市重点实验室，北京，100034；
    4国家药品监督管理局化妆品质量控制与评价重点实验室，北京，100034
  • 出版日期:2022-09-15 发布日期:2022-07-13

Mycobacterium murinum skin infection: a case report

CHEN Yan1, 2, 3, 4, SHANG Panpan1, 2, 3, 4, SONG Yinggai1, 2, 3, 4, WANG Mingyue1, 2, 3, 4   

  1. 1 Department of Dermatology, Peking University First Hospital, Beijing 100034, China;
    2 National Clinical Research Center For Skin and Immune Diseases，Beijing 100034, China;
    3 Beijing Key Laboratory of Molecular Diagnosis on Dermatoses，Beijing 100034, China;
    4 NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics，Beijing 100034, China
  • Online:2022-09-15 Published:2022-07-13

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摘要： 患者，女，38岁。处理海鲈鱼时，双手多处被鱼刺扎伤。后于受伤部位出现浸润性斑块、溃疡。清创治疗、抗细菌及抗真菌治疗无效。组织活检病理提示感染性肉芽肿，组织培养海分枝杆菌阳性，组织DNA行特异性real time PCR检测海分枝杆菌阳性。予以患者利福平、克拉霉素、乙胺丁醇治疗3个月，皮疹完全消退。随访一年未复发。

关键词: 海分枝杆菌, 感染性肉芽肿, 鱼刺伤肉芽肿, 非典型分枝杆菌

Abstract: A 38-year-old female's both hands were injured by fish bones when dealing with sea bass. Later infiltrating plaques and ulcerations appeared at the injured sites. Debridement, antimicrobial and antifungal therapy were not effective. The pathological examination showed infectious granuloma. Additionally, Mycobacterium murinum was identified by tissue culture and DNA detection. After 3 months of treatment with rifampicin, clarithromycin and ethambutol, the lesions subsided completely, leaving atrophic scars. No recurrence was observed among one-year followup.

Key words: Mycobacterium riummurinum, infectious granuloma, fish stabbed granuloma, atypical mycobacterium