中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (6): 417-419.doi: 10.12144/zgmfskin202306417

• 临床研究 • 上一篇    下一篇

国内首报皮肤美容分枝杆菌感染一例

曹珊,暴芳芳,赵晴,方梦,陈声利,张福仁   

  1. 山东第一医科大学附属皮肤病医院(山东省皮肤病医院)，山东省皮肤病性病防治研究所
  • 出版日期:2023-06-15 发布日期:2023-05-18

First report of Mycobacterium cosmeticum in China

CAO Shan, BAO Fangfang, ZHAO Qing, FANG Meng, CHEN Shengli, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2023-06-15 Published:2023-05-18

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摘要： 美容分枝杆菌作为一种少见的非典型分枝杆菌，可导致皮肤肉芽肿疾病。现国内首报一例患者，女，22岁。右手背被猫咬伤后出现暗红色斑2个月。既往体健。组织病理符合感染性肉芽肿，倾向非典型分枝杆菌感染；皮肤组织测序并进行系统和发育树分析，最终诊断为美容分枝杆菌（Mycobacterium cosmeticum）感染。该患者治疗时间较长，多次调整用药，最终应用环丙沙星、克拉霉素联合米诺环素，皮损完全消退。

关键词: 美容分枝杆菌感染, 感染性肉芽肿

Abstract: As a rare atypical mycobacterium, Mycobacterium cosmeticum can cause cutaneous granuloma. We report the first case in China of Mycobacterium cosmeticum infection. A 22-year-old female presented with erythema on the right arm for cat bite for 2 months and the past medical history was healthy. The histopathology was consistent with infectious granuloma and tended to atypical mycobacterium infection. The skin tissue was sequenced and the phylogenetic tree analysis was carried out. The final diagnosis was Mycobacterium cosmeticum infection. After the long-term treatments with adjusted medication, the lesion subsided by using condition by using ciprofloxacin, clarithromycin, and minocycline.

Key words: Mycobacterium cosmeticum, infective granuloma