中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (1): 25-29.doi: 10.12144/zgmfskin202601025

• 论著 • 上一篇    下一篇

天疱疮患者疾病严重程度与抑郁、焦虑及生活质量的相关性

Gyeongah Kim1,李鲁源2,胡宏香1,李佶姝1,王怡怡1,冯迅1,魏敏童1,许可沁1,周兴丽1,3,李薇1,3   

  1. 1四川大学华西医院皮肤性病科，四川成都，610041； 2南方医科大学第一临床医学院，广东广州，510515； 3四川大学华西医院罕见病中心，四川成都，610041
  • 出版日期:2026-01-15 发布日期:2026-01-15

Association between disease severity and depression, anxiety, and quality of life in pemphigus patients

KIM Gyeongah1, LI Luyuan2, HU Hongxiang1, LI Jishu1, WANG Yiyi1, FENG Xun1, WEI Mintong1, XU Keqin1, ZHOU Xingli1,3, LI Wei1,3   

  1. 1 Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China; 2 The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; 3 Center for Rare Diseases, West China Hospital, Sichuan University, Chengdu 610041, China
  • Online:2026-01-15 Published:2026-01-15

PDF (PC)

7

摘要： 目的：明确天疱疮疾病严重程度与抑郁、焦虑及生活质量的相关性。方法：选取2024年8月至2025年2月四川大学华西医院皮肤性病科天疱疮患者，采用BDI-Ⅱ、BAI和DLQI量表分别评估其抑郁、焦虑及生活质量，并记录天疱疮疾病面积指数（PDAI）。同期健康人群为对照组。结果：共纳入104例天疱疮患者、62名正常对照，患者组BDI-Ⅱ、BAI及DLQI得分均高于对照组（均P＜0.05）。PDAI与BDI-Ⅱ（r=0.277）、BAI（r=0.201）呈弱正相关，与DLQI（r=0.401）呈中度正相关（均P＜0.05）；BDI-Ⅱ、BAI与DLQI之间均呈强正相关（r≥0.621，P＜0.01）。回归分析显示，PDAI对BDI-Ⅱ、BAI及DLQI均有显著正向影响（均P＜0.05）。结论：天疱疮患者抑郁、焦虑水平较高，生活质量较差，且均与疾病严重程度正相关。临床应关注心理健康并给予干预，以改善预后。

关键词: 天疱疮, 疾病严重程度, 抑郁, 焦虑, 生活质量

Abstract: Objective: To clarify the correlation between the severity of pemphigus and depression, anxiety, and quality of life. Methods: Pemphigus patients in the department of dermatology from August 2024 to February 2025 were selected. The Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and Dermatology Life Quality Index (DLQI) were used to assess depression, anxiety, and quality of life, respectively. The Pemphigus Disease Area Index (PDAI) was recorded. Healthy individuals during the same period served as the control group. Results: A total of 104 pemphigus patients and 62 healthy controls were included. The scores of BDI-II, BAI, and DLQI in the patient group were significantly higher than those in the control group (Ps＜ 0.05). PDAI was weakly positively correlated with BDI-II (r = 0.277) and BAI (r=0.201), and moderately positively correlated with DLQI (r = 0.401) (Ps＜ 0.05). Strong positive correlations were observed between BDI-II, BAI, and DLQI (r≥0.621, P＜0.01). Regression analysis showed that PDAI had a significant positive impact on BDI-II, BAI, and DLQI (Ps＜0.05). Conclusion: Pemphigus patients exhibit higher levels of depression and anxiety, as well as poorer quality of life, all of which are positively correlated with disease severity. Clinical attention should be paid to mental health and corresponding interventions should be provided to improve prognosis.

Key words: pemphigus, disease severity, depression, anxiety, quality of life