中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (3): 221-224.doi: 10.12144/zgmfskin202603221

• 综述 • 上一篇    

IgE在银屑病中的研究进展

向志,郝志敏,马一平,李诚让   

  1. 中国医学科学院,北京协和医学院皮肤病医院，江苏南京,210042
  • 出版日期:2026-03-15 发布日期:2026-03-10

Research progress on elevated serum IgE in psoriasis

XIANG Zhi, HAO Zhimin, MA Yiping, LI Chengrang   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu 210042, China
  • Online:2026-03-15 Published:2026-03-10

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摘要： 银屑病是皮肤科常见慢性复发性疾病，其发病与IL-23/Th17反应轴密切相关，常伴发心血管疾病。IgE主要由Th2免疫反应介导生成，近年来发现银屑病患者血清中IgE增加，并且血清IgE水平与心肌梗死等缺血性心脏病存在关联，因此IgE可能参与银屑病及其心血管共病的发病。本文主要针对IgE与银屑病、银屑病共病及生物制剂治疗后出现免疫漂移等相关性及潜在机制予以系统总结，以期为银屑病患者中开展IgE的研究及相关治疗提供新思路及新靶点。

关键词: 银屑病, IgE, 发病机制, 生物制剂, 免疫漂移

Abstract: Psoriasis is a common chronic recurrent dermatological disease which often associated with cardiovascular diseases. IgE is primarily produced through Th2 immune responses. Recent studies have revealed elevated serum IgE is common in psoriasis patients, while elevated serum IgE is linked to ischemic heart diseases such as myocardial infarction as well. Elevated serum IgE may related to immune drift following biologic treatments in psoriasis patients. Therefore, IgE may play a role in the pathogenesis of psoriasis, cardiovascular comorbidities and immune drift. This review systematically summarizes the correlations and potential mechanisms between IgE and psoriasis, its comorbidities, as well as immune drift following biologic treatments, aiming to provide new insights for IgE-related research in psoriasis patients.

Key words: psoriasis, IgE, pathogenesis, biologics, immune drift