中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (2): 139-144.doi: 10.12144/zgmfskin202602139

• 综述 • 上一篇    

蛋白质翻译后修饰在银屑病中的研究进展

胡珺婕1,2,3,4,吴一凡1,2,3,4,汤华阳1,2,3,4   

  1. 1安徽医科大学第一附属医院皮肤科，安徽合肥，230032； 2安徽医科大学皮肤病研究所，安徽合肥，230032； 3皮肤病学教育部重点实验室（安徽医科大学），安徽合肥，230032； 4疑难重症皮肤病协同创新中心，安徽医科大学，安徽合肥，230032
  • 出版日期:2026-02-15 发布日期:2026-01-28

Post-translational modifications and psoriasis: from molecular mechanisms to therapeutic targets

HU Junjie1,2,3,4, WU Yifan1,2,3,4, TANG Huayang1,2,3,4   

  1. 1 Department of Dermatology, the First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; 2 Institute of Dermatology, Anhui Medical University, Hefei 230032, China; 3 Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei 230032, China; 4 Collaborative Innovation Center of Complex and Severe Skin Disease, Anhui Medical University, Hefei 230032, China
  • Online:2026-02-15 Published:2026-01-28

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摘要： 翻译后修饰作为调控蛋白质生物学功能的核心环节，其修饰酶及其底物的表达异常已被证实与银屑病发病有关。本文综述了常见蛋白质翻译后修饰，及其在银屑病发病中的作用包括失调的翻译后修饰会影响关键底物如NF-κB、STAT3、角蛋白和IL-17A的功能，从而放大Th17/Th1反应、导致角质形成细胞过度增殖、血管生成和中性粒细胞胞外诱捕网的形成等。

关键词: 银屑病, 蛋白质翻译后修饰, 组蛋白

Abstract: Post-translational modification (PTM) serves as a core step in regulating the biological functions of proteins. Dysregulated expression of PTM-related enzymes and their substrates has been confirmed to be associated with the pathogenesis of psoriasis. This review summarizes common types of protein post-translational modifications and their roles in the pathogenesis of psoriasis, including that aberrant post-translational modifications can affect the functions of key substrates such as NF-κB, STAT3, keratin and IL-17A, thereby amplifying the Th17/Th1 immune response, inducing excessive proliferation of keratinocytes, promoting angiogenesis, and facilitating the formation of neutrophil extracellular traps (NETs).

Key words: psoriasis, post-translational modification, histone