中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (9): 683-688.doi: 10.12144/zgmfskin202609683

• 综述 • 上一篇    

空气污染致皮肤损伤的分子机制及防护研究进展

刘智1,韩齐心2,闫辰旭1,李昌钰3,牛旭平2   

  1. 1 山西医科大学第九临床医学院，山西太原，030001；2太原市中心医院皮肤科，山西太原，030009；3 长治医学院第一临床学院，山西长治，046000
  • 出版日期:2026-09-15 发布日期:2026-09-02

Research progress on the molecular mechanisms and protection of air pollution-induced skin damage

LIU Zhi1, HAN Qixin2, YAN Chenxu1, LI Changyu3, NIU Xuping2   

  1. 1 The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China; 2 Department of Dermatology, Taiyuan Central Hospital, Taiyuan 030009, China; 3 The First Clinical College of Changzhi Medical College, Changzhi 046000, China
  • Online:2026-09-15 Published:2026-09-02

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摘要： 空气污染物主要包括颗粒物、多环芳烃及气态污染物，主要通过诱导氧化应激、激活炎症信号通路、介导芳烃受体毒性应答、破坏皮肤屏障等多条途径协同作用。防护策略包括抗氧化、抗炎信号调控、细胞器保护、屏障修复及皮肤微生态调节等。本文综述了空气污染致皮肤损伤的分子机制及相关防护策略的研究进展，以期为后续研究与临床防护提供参考。

关键词: 空气污染, 皮肤损伤, 氧化应激, 芳烃受体, 防护策略

Abstract: Air pollutants primarily include particulate matter, polycyclic aromatic hydrocarbons, and gaseous pollutants. They act synergistically mainly through multiple pathways, including inducing oxidative stress, activating inflammatory signaling pathways, mediating aryl hydrocarbon receptor (AhR)-dependent toxic responses, and disrupting the skin barrier. Protective strategies include antioxidant and anti-inflammatory signaling regulation, organelle protection, barrier repair, and modulation of the skin microecology. We review the research progress on the molecular mechanisms of air pollution-induced skin damage and related protective strategies, aiming to provide a reference for future research and clinical protection.

Key words: air pollution, skin damage, oxidative stress, aryl hydrocarbon receptor, protective strategies