中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (10): 614-615.

• 短篇论著 • 上一篇    下一篇

破伤风抗毒素所致药疹42例临床特点分析

邵成明，陈婷婷，葛永兴，张敏杰   

  1. 苏州大学附属太仓医院，太仓市第一人民医院皮肤科，江苏太仓，215400
  • 出版日期:2016-10-15 发布日期:2018-12-19
  • 通讯作者: 邵成明，E-mail: ssghx@163.com

Clinical features of 42 patients with drug eruption caused by tetanus antitoxin injection

SHAO Chengming, CHEN Tingting, GE Yongxing, ZHANG Minjie   

  1. Department of Dermatology, Taicang Hospital Affiliated to Suzhou University, Taicang First People's Hospital, Suzhou 215400, China
  • Online:2016-10-15 Published:2018-12-19
  • Contact: SHAO Chengming, E-mail: ssghx@163.com

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摘要： 目的：明确破伤风抗毒素所致药疹的临床特点。方法：对42例破伤风抗毒素所致药疹的临床资料进行回顾性分析。结果：42例患者中破伤风抗毒素皮试阴性40例，阳性2例。发疹潜伏期6 ~12天，平均为6.5天，皮疹表现为注射局部红斑2例，全身泛发性皮疹40例(发疹型6例，荨麻疹型32例，多型红斑型2例)。42例患者中伴发热5例，呕吐5例，关节痛12例。糖皮质激素治疗有效。结论：破伤风抗毒素所致药疹最常见类型为荨麻疹型，可伴发热、消化道症状及关节痛。药疹的发生与皮试结果无关。

关键词: 破伤风抗毒素, 药疹, 皮试

Abstract: Objective: To determine the clinical characteristics of drug eruption caused by tetanus antitoxin injection. Methods: The clinical data of 42 cases with drug eruption caused by tetanus antitoxin were analyzed respectively. Results: The skin test was negative in 40 patients and positive in 2 patients. Incubation was 6 to 12 days and the average incubation was 6.5 days. The lesions were presented as erythema in injection area in 2 patients and as generalized rash in 40 patients (exanthematous type in 6 patients, urticaria type in 32 and erythema multiforme type in 2). Five of 42 patients accompanied with fever, 5 with voimt and 12 with joint pain. Glucocorticoid was effective in the treatment.Conclusion: The common type of drug eruption caused by tetanus antitoxin injection is urticaria type and some patients have fever, voimt and joint pain. There is no correlation between the drug eruption caused by tetanus antitoxin injection and the result of skin test.

Key words: tetanus antitoxin, drug eruption, skin test