中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (4): 199-202.

• 论著 • 上一篇    下一篇

TOX 与 Notch1在MF中的表达

赵 晶1，2 ，张福仁2，王建文2，陈声利2，周桂芝2，刘永霞2，，陈学超2卢宪梅2   

  1. 1 济南大学山东省医学科学院医学与生命科学学院，济南，250000 2 山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2016-04-15 发布日期:2018-12-24
  • 通讯作者: 卢宪梅，E-mail：xinmeilu2013@163.com

TOX and Notch1 expression in mycosis fungoides

ZHAO Jing1,2, ZHANG Furen2, WANG Jianwen2, CHEN Shengli2, ZHOU Guizhi2, LIU Yongxia2, CHEN Xuechao2, LU Xianmei2.   

  1. 1.Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China 2.School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250062, China
  • Online:2016-04-15 Published:2018-12-24
  • Contact: LU Xianmei, E-mail：xinmeilu2013@163.com

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摘要： 目的：检测TOX蛋白及活化型Notch1蛋白在MF中的表达情况，探讨TOX及Notch1蛋白作为MF分子标记物的可行性。方法：采用免疫组化方法检测35例MF（15例斑片期，10例斑块期，10例肿瘤期）和45例对照组（15例淋巴瘤样丘疹病、15例扁平苔藓、15例银屑病）的病理组织标本中TOX蛋白及活化型Notch1蛋白的表达。结果：TOX蛋白染色结果：MF阳性率约94.3%，且阴性标本全部为斑片期，对照组阳性率75.6%。MF组TOX蛋白表达强度高于对照组比较，差异有统计学意义(P<0.05)。 MF组与对照组所有病例肿瘤细胞Notch1阴性。 结论： MF组与对照组TOX蛋白表达水平有显著差异性，但还不足以证明TOX可作为诊断MF的分子标记物，需进一步验证。Notch1蛋白不在皮肤T细胞淋巴瘤中表达 ，故无法作为MF的分子标记物。

关键词: 皮肤T细胞淋巴瘤, 蕈样肉芽肿, TOX, Notch信号通路, Notch1

Abstract: Objective: To detect the expression of TOX and Notch1 protein in for mycosis fungoides (MF) and to determine the role as a potential molecular markers for MF．Methods: TOX and Notch1 protein were detected by immunohistochemical staining in the lesions of 35 patients with MF (15 patients at patch stage, 10 at plaque stage and 10 at tumour stage) and in 45 controls (15 patients with lymphomatoid papulosis, 15 with lichen planus and 15 with psoriasis). Result: The positivity rate of TOX in the patients with MF was 94.3％ and 76％ in controls. The level of TOX protein expression was higher in MF patients than in controls (P<0.05). Notch1 protein was negative in tumor cells of all MF patients and controls. Conclusion: Although TOX expression level was higher in MF patients, TOX protein can not be used as a potential molecular marker for MF and further experimental studies should be performed. Notch1 protein is not a molecular marker for MF.

Key words: cutaneous T-cell lymphomas, MF, TOX, Notch signaling pathways, Notch1