中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (5): 260-262.

• 论著 • 上一篇    下一篇

308 nm准分子激光对轻度斑块状银屑病患者外周血Th17细胞因子的影响

陆家睛，易雪梅，于 宁，陈福娟，丁杨峰   

  1. 上海市皮肤病医院，上海200443
  • 出版日期:2016-05-15 发布日期:2018-12-24
  • 通讯作者: 丁杨峰，E-mail：mmmm_111111@126.com

Effects of 308 nm excimer laser on the Th17 cytokines in the patients with mild plaque psoriasis

LU Jiajing, YI Xuemei, YU Ning, CHEN Fujuan, DING Yangfeng.   

  1. Shanghai Skin Diseases Hospital, Shanghai 200443, China
  • Online:2016-05-15 Published:2018-12-24
  • Contact: DING Yangfeng, E-mail：mmmm_111111@126.com

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摘要： 目的: 确定308 nm准分子激光对轻度斑块状银屑病患者外周血Th17细胞相关细胞因子的表达的影响。方法:采用ELISA方法检测308 nm准分子激光治疗前后60轻度斑块状银屑病患者及20例健康正常人血清中IL-17和IL-22的含量。结果:银屑病患者308 nm准分子激光治疗前外周血IL-17和IL-22的表达水平为98.14±27.83ng/L 和73.17±20.53ng/L，高于正常对照组的44.25±12.64ng/L和19.56±6.61ng/L，差异有统计学意义（P＜0.01）；治疗后银屑病患者外周血IL-17和IL-22水平下将至51.73±26.32 ng/L和25.24±18.16ng/L，与治疗前比较差异有统计学意义（P＜0.01）。结论: 308 nm准分子激光可调节外周血IL-17和IL-22的水平。

关键词: 轻度斑块状银屑病, 308 nm准分子激光, IL-17, IL-22

Abstract: Objective: To determine the effects of 308 nm excimer laser on the levels of Th17 cytokines in the patients with mild plaque psoriasis. Methods: The levels of IL-17 and IL-22 in 60 patients with mild plaque psoriasis and 20 healthy controls were detected by ELISA. Results: The levels of IL-17and IL-22 in patients before treatment were (98.14±27.83) ng/L and (73.17±20.53) ng/L and those in controls were (44.25±12.64) ng/L and (19.56±6.61) ng/L, with significant differences (P＜0.01). The levels of IL-17and IL-22 in the patients after treatment decreased to (51.73±26.32) ng/L and (25.24±18.16) ng/L. The differences in the levels of IL-17 and IL-22before and after the treatment were significant (P＜0.01). Conclusion: 308 nm excimer laser can regulate the levels of Th17 cytokines in the patients with mild plaque psoriasis.

Key words: mild plaque psoriasis, 308 nm excimer laser, IL-17, IL-22