中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (11): 649-652.

• 论著 • 上一篇    下一篇

伴发甲状腺功能减低的皮肌炎临床和免疫学特征

陈国梁1  徐兰2  徐金华1   

  1. 1复旦大学附属华山医院皮肤科，上海，200040
    2复旦大学附属华山医院老年病科，上海，200040
  • 出版日期:2017-11-15 发布日期:2018-12-11
  • 通讯作者: 徐兰，E-mail:13816586496@163.com

Clinical analysis of patients with dermatomyositis and thyroid dysfunction

CHEN Guoliang1，XU Lan2， XU Jinhua1.   

  1. 1. Department of Dermatology, Fudan University Huashan Hospital, Shanghai 200040, China; 2. Department of Geratology, Fudan University Huashan Hospital, Shanghai 200040, China
  • Online:2017-11-15 Published:2018-12-11
  • Contact: XU Lan, E-mail: 13816586496@163.com

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摘要： 目的：明确伴发甲状腺功能减低的皮肌炎患者的临床及免疫学特征。方法：回顾性分析2010年1月至2014年12月我院皮肤科确诊的195例DM患者的临床表现、肌酶水平、自身抗体、C反应蛋白、免疫球蛋白、血脂等指标，依据甲状腺功能情况进行分组比较。结果：195例DM患者中甲状腺功能异常者达56.41%,主要表现为甲状腺功能减低，尤其是低T3综合征。与甲状腺功能正常组比较,甲状腺功能异常组的患者多见发热、Gottron征、向阳疹、V型征，也常出现CRP和IgG升高，两组患者系统器官受累情况及肿瘤发生率比较差异无统计学意义。结论：DM患者甲状腺功能减低发生率高，两者可能存在共同的免疫机制。

关键词: 皮肌炎, 甲状腺功能, 免疫学

Abstract: Objective: To analyze the clinical features of dermatomyositis (DM) complicated with thyroid dysfunction. Methods: The clinical and laboratory data including antibodies, C reactive protein (CRP), immunoglobulin and serum lipid levels of 195 patients with DM from 2010 to 2014. Results: Out of 195 patients, 56.41% patients had thyroid dysfunction and most of them suffered from subclinical hypothyroidism and low T3 syndrome. DM patients with thyroid dysfunction were more likely to have higher levels of CRP and IgG as well as Gottron sign, fever and erythema. There was no significant difference in the number of patients with internal organ involvement and tumors between the two groups. Conclusion: The subclinical thyroid dysfunction is high in the patients with DM and there may be a common immunological background in the two diseases.

Key words: dermatomyositis, hypothyroidism, immunology