鳞状细胞癌,Bowen病,日光性角化病,Raptor,Rictor ," /> 鳞状细胞癌,Bowen病,日光性角化病,Raptor,Rictor ,"/> Squamous cell carcinoma,Bowen's disease,actinic keratosis,Raptor,Rictor ,"/> <p class="MsoNormal"> Raptor<span>、</span><span>Rictor</span><span>和磷酸化</span><span>Akt</span><span>在日光性角化病、</span><span>Bowen</span><span>病及鳞状细胞癌中的表达</span>

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (3): 132-136.

• 论著 • 上一篇    下一篇

Raptor、Rictor和磷酸化Akt在日光性角化病、Bowen病及鳞状细胞癌中的表达

周萌1  刘保国2  顾静1  苗国英2  李小静2  刘青2   

  1. 1承德医学院研究生院，河北承德,067000

    2河北工程大学附属医院皮肤科，河北邯郸,056002

  • 出版日期:2017-03-15 发布日期:2018-12-14
  • 通讯作者: 刘保国，E-mail：lbg66@163.com

Expression of Raptor, Rictor and p-Akt in actinic keratosis, Bowen's disease and squamous cell carcinoma

ZHOU Meng1, LIU Baoguo2, GU Jing1, MIAO Guoying2, LI Xiaojing2, LIU Qing2   

  1. 1. Postgraduate School, Chengde Medical College, Chengde 067000, China;

    2. Department of Dermatology, the Hospital Affiliated to Hebei Engineering University, Handan 056002, China

  • Online:2017-03-15 Published:2018-12-14
  • Contact: LIU Baoguo, E-mail: lbg66@163.com

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摘要：

目的：检测Raptor、Rictor和磷酸化Akt（p-Akt）在日光性角化病、Bowen病和鳞状细胞癌中的表达。方法：采用免疫组化法检测Raptor、Rictor及p-Akt（Ser473）在20例正常皮肤、20例日光性角化病、20例Bowen病及40例鳞状细胞癌中的表达。结果：Raptor在鳞状细胞癌、Bowen病和日光性角化病中的阳性表达率分别为87.50%、70.00%和60.00%，均高于正常皮肤的25.00%（均P<0.05）；其中低分化鳞状细胞癌中Raptor的阳性表达率为100%，高于高分化鳞状细胞癌的阳性表达率75%（P<0.05）。Rictor在鳞状细胞癌、Bowen病和日光性角化病中的阳性表达率分别为80.00%、70.00%及55.00%，均高于正常皮肤阳性表达率的20%（均P<0.05）；p-Akt（Ser473）在鳞状细胞癌、Bowen病和日光性角化病中的阳性表达率分别为77.50%、65.00%及50.00%，而正常皮肤阳性表达率为0。鳞状细胞癌、Bowen病和日光性角化病中Rictor的阳性表达水平和p-Akt（Ser473）的阳性表达水平均呈正相关(均P<0.05)。结论：Raptor、Rictor和p-Akt（Ser473）的高表达可能与日光性角化病、Bowen病和鳞状细胞癌的发生发展有关。

关键词: 鳞状细胞癌')">

鳞状细胞癌, Bowen病, 日光性角化病, Raptor, Rictor

Abstract:

Objective:To detect the expression of Raptor, Rictor and p-Akt in the lesions of actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC). Methods: Immunohistochemistry was used to detect the expression of Raptor, Rictor, p-Akt (Ser473) in the tissue samples from the patients with AK, BD, SCC and normal human skin. Results: The positivity rates of Raptor in SCC, BD and AK were 87.50%, 70.00% and 60.00%, which was significantly higher than that in normal skin (Ps<0.05). The positivity rate was 100% in poorly differentiated squamous cell carcinoma and 75% in well differentiated squamous cell carcinomas, with a significant difference (P<0.05). The positivity rates of Rictor in SCC, BD and AK were 80.00%, 70.00% and 55.00%, which was significantly higher than that in normal skin (P<0.05). The positivity rates of p-Akt (Ser473) in SCC, BD and AK were 77.50%, 65.00% and 50.00%, while there was no positive staining in normal skin. There was a positive correlation between the expression level of Rictor and p-Akt (Ser473) in SCC, BD and AK (P<0.05). Conclusion: The high expression of Raptor, Rictor and p-Akt (Ser473) may play a key role in the occurrence and development of AK, BD and SCC.

Key words: Squamous cell carcinoma')">

Squamous cell carcinoma, Bowen's disease, actinic keratosis, Raptor, Rictor